Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

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This article is for informational purposes and does not constitute medical advice. Always consult your doctor before starting or stopping any medication.

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1. •Talk to your doctor before taking nitrates or alpha-blockers.
2. If you are taking any other medications, including prescription drugs, nonprescription medications, and herbal supplements.
3. If you are taking any herbal or vitamin supplements

For prescription medications, read theMDalemedication guide provided by your healthcare provider. Check the provider’s website or call 1-800-467-5146 for expert guidance.

1. Always speak to your doctor before taking alcohol or other medications while taking any medication.
2. If you are pregnant or plan to become pregnant, consult your doctor before taking medications while taking alcohol or other medications.

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What are the symptoms of erectile dysfunction?

If you want to understand the underlying cause of your problem, you can try to start with the following tips:

• Take a look at the symptoms of erectile dysfunction. There is no cure for this condition. This means that you need to find an effective treatment for it. It can be quite expensive.
• Try to avoid sex, and don’t get it up until you have sex.
• Be aware of the fact that it can cause many other conditions. For instance, if you have a condition that causes impotence, you will have a very low chance of it.
• Be mindful of any other medical conditions and seek help for these.

If you are experiencing your erections, you may not have a problem. But you should seek medical help for other conditions. Your doctor can provide you with a complete list of the various factors that may cause your erectile dysfunction, and help you find a solution.

Why is erectile dysfunction treatment different to Viagra?

Viagra (sildenafil) is a drug that is used to treat erectile dysfunction in men. The drug belongs to the class of medications called phosphodiesterase-5 inhibitors. This medication relaxes blood vessels, increasing blood flow to the penis, and makes it easier for men to get and keep an erection. This drug is available in a tablet, and you can buy it in a tablet and then take it as needed. It works in one of the most common erectile dysfunction treatments:

• It works by helping men to get and keep an erection, which allows them to maintain that erection for an extended period.
• It is available in two forms:
• A pill that is taken in pill form
• A chewable tablet that contains the active ingredient sildenafil.

How does it work?

Viagra (sildenafil) works by helping the blood vessels in your penis to relax, allowing you to get and keep an erection. This medication is available in a tablet, and you can buy it in a tablet and take it as needed. It is also available in a pill, and you can buy it in a pill and then take it as needed.

• A tablet that contains the active ingredient sildenafil.
• It is available in four different forms:
• It is available in four different strengths:
• The most common strength of sildenafil is 5 mg, which is the dose that comes in tablet form.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire information

What is Tadalafil?

Tadalafil is the generic version of the prescription medication Cialis. This Tadalafil is used to help treat both conditions – and Tadalafil is also used as a way to guarantee that men who are experiencing symptoms of diabetes such as painful gyno, nausea, vomiting, and headache will reassure their GP that they are on a diet.

Tadalafil is available in the form of :

• Eachoxan® (Generic angiotensin-converting enzyme) is a brand of Tadalafil, which is the active ingredient in it. It is used to treat is type 2 diabetes. (Ixar)

• Cialis is also used to treat high blood pressure.

• Cialis is an at-home medicine that can’t be taken by mouth.

How do I take Tadalafil?

Please ensure your doctor is ammonised before this medication. If you have any questions about how to take Tadalafil or any other medicine, please speak to your doctor.

What are the possible side effects of Tadalafil?

Side effects can include:

• Nausea
• Diarrhoea
• Dizziness
• Increased pressure in the brain
• Other effects

Please discuss these with your doctor. There can be a few side effects that will be listed below with your doctor:

• Liver function changes
• Low blood pressure
• Allergic reactions

There may be other side effects that you can discuss with your doctor. You will be asked a series of questions about those other side effects.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

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Cialis and Other Drug-Food Interactions:

Similar to name drug, drug-food Interaction for Cialis (tadalafil) is dependent on food, medical history, and medical condition. It is suggested that you please speak with a doctor before using Cialis with any food or medical condition, as it may lead to increased side effects.

Patients should exercise caution when taking Cialis with other drugs that may interact with tadalafil. Selective serotonin reuptake inhibitors (SSRIs) and sildenafil (Viagra) are these drugs that have been used off-label-to-reating erectile dysfunction (ED) for centuries. While they work to treat ED, SSRIs may damage blood vessels, increase the risk of blood clots, or slow heart rate in sensitive individuals. These effects of sildenafil are similar to those of tadalafil. Avoid taking sildenafil while taking Cialis, as it may damage the blood vessels, increase the risk of blood clots, or slow heart rate in sensitive individuals.